"SYNGO: a bioinformatic approach to the synapse and synaptic pathways in brain disease"

Chemical synapses are the fundamental computational units of the brain. They adapt their efficacy dependent on recent activity and modulatory signals, while mal-adaptation is a central aspect in many brain disorders (synaptopathies) and loss of synaptic connectivity is a final common pathway for several neurodegenerative disorders. Despite decades of intense research, no systematic annotation of synaptic genes and pathways existed, precluding the bioinformatic exploitation of synapse biology knowledge. We have recently established SYNGO, a worldwide consortium to change this situation and provide evidence-based, expert-curated definition of synaptic genes and pathways, synapse functions and synapse diversity, and compounds that target these pathways and
functions in a computer-readable format.

In this presentation, we will review SYNGO synapse models, adapting Gene Ontology (GO) annotation (>3000 annotations for >1000 synaptic genes), phylogenetic profiling maps and enrichment studies using gene-set analyses in genome-wide association data and large scale proteomics. New directions towards curation of protein-protein interactions in the synapse (SYNGO2.0) and causality mapping (SYNGO4.0) will be discussed. Taken
together, SYNGO provides a unique, public resource as a universal reference to support synapse research, for gene enrichment studies in disease and to design intervention strategies.

Attention: La présentation d'un certificat covid et d'une pièce d'identité est obligatoire pour accéder à la salle de conférence.