Stem Cells in the Adult Brain: Regulation and Diversity.

Neural stem cells reside in specialized niches in the adult mammalian brain. Adult neural stem cells dynamically integrate intrinsic and extrinsic signals to either maintain the quiescent state or to become activated to divide and generate neurons and glia. I will present our recent findings highlighting adult neural stem cell heterogeneity, including the identification of novel gliogenic domains and cell types, and the key roles of physiological states and long-range signals in the regulation of regionally distinct pools of adult neural stem cells.