Research Highlights
In 2017, we shown that complex trait associated lincRNAs often regulate gene expression in cis through modulation of local chromosomal architecture cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture. Behind the scenes we were busy establishing approaches to determine RNA metabolic rates, RNA mediated DNA-DNA contacts and genome-edited lines to investigate some of our favourite noncoding RNAs. These tools will allow us, in the coming months, to test a few of the hypothesis we and others have generated over the years using comparative and functional genomics.
