Group Tatiana Petrova

Kivelä R., Salmela I., Nguyen Y.H., Petrova T.V., Koistinen H.A., Wiener Z., Alitalo K. The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. Nat Commun, 7:13124 Pubmed

Poulin A., Saygili Demir C., Rosset S., Petrova T.V., Shea H. Dielectric elastomer actuator for mechanical loading of 2D cell cultures. Lab Chip, 16(19):3788–94, 2016 Pubmed

Bernier-Latmani J., Petrova T.V. High-resolution 3D analysis of mouse small-intestinal stroma. Nat Protoc, 11(9):1617–29, 2016 Pubmed

Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y. Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis. Head Neck, 2016 Pubmed

Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y. Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification. Head Neck, 38(9):1407–15, 2016 Pubmed

Kerr B.A., West X.Z., Kim Y-W., Zhao Y., Tischenko M., Cull R.M., Phares T.W., Peng X.D., Bernier-Latmani J., Petrova T.V., Adams R.H., Hay N., Naga Prasad S.V., Byzova T.V. Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. Nat Commun. 7, 2016 Pubmed

Demaria O., De Gassart A., Coso S., Gestermann N., Di Domizio J., Flatz L., Gaide O., Michielin O., Hwu P., Petrova T.V., Martinon F., Modlin R.L., Speiser D.E., Gilliet M. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci U S A, 112, 15408–13, 2016 Pubmed

Pfenniger, A., Meens, M.J., Pedrigi R.M., Foglia B., Sutter E., Pelli G., Rochemont V., Petrova T.V., Krams R., Kwak B.R. Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37. Atherosclerosis, 243, 1-10, 2015 Pubmed

Bernier-Latmani, J., Cisarovsky, C., Saygili Demir, C., Bruand, M., Jaquet, M., Davanture, S., Ragusa, S., Siegert, S., Dormond, O., Benedito, R., Radtke, F., Luther, S.A., & Petrova, T.V. DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J. Clin. Invest., 2015 (journal cover) Pubmed

Sabine, A., Bovay ,E., Saygili Demir, C., Kimura, W., Jaquet, M., Agalarov, Y., Zangger, N., Scallan, J.P.,  Graber, W.,  Gulpinar, E., Mäkinen, T., Martinez-Corral, I., Ortega, S., Delorenzi, M., Kiefer, F., Davis, M.J., Djonov, V., Miura, N., Petrova, T.V. Foxc2 and fluid shear stress stabilize postnatal lymphatic vasculature. J. Clin. Invest. 125, 3861-77, 2015 - ranked “Exceptional” by F1000 Pubmed

Kazenwadel J., Betterman, K.L., Chong, C.H, Stokes , P.H., Lee Y.K., Secker, G.A., Agalarov, Y., Saygili, C., Lawrence, D.M., Sutton, D.L., Tabruy, S.P., Miura, N., Salminen, M., Petrova, T.V., Matthews, J.M., Hahn, C., Scott, H., Harvey, N.L., GATA2 haploinsufficiency predisposing to lymphedema reveals key roles in lymphatic vascular development , J. Clin. Invest. 125, 2979-94, 2015. Pubmed

Liebl, J., Moser, M., Agalarov, Y., Saygili, C.D., Zhang, S., Hager, B., Bibb, J.A., Adams, R.H., Kiefer, F., Miura, N., Petrova, T.V., Vollmar, A.M., Zahler, S. Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2 , Nat. Commun. 6, 72-74, 2015. Pubmed

Ragusa, S., Cheng, J., Ivanov, K.I., Zangger, N., Ceteci, F.,Bernier-Latmani, J., Milatos, S., Joseph, J.-M., Tercier, S.,, Bouzourene, H.,  Bosman, F., Letovanec, I., Marra, G., Gonzalez1, M., Cammareri, M., Sansom, O., Delorenzi, M., Petrova T.V., PROX1 promotes metabolic adaptation and fuels outgrowth of Wnthigh metastatic colon cancer cells. Cell Reports, 8, 1957-73, 2014. Pubmed

Zheng,W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E., Orsenigo, F., Lohela,M., D’Amico, G., Holopainen, T., Leow, C., Dejana, E., Petrova, T.V., Augustin, H.G., Alitalo, K. Angiopoietin-2 regulates the transformation and integrity of lymphatic endothelial cell junctions, Genes&Dev., 8, 1592-6032014, 2014. Pubmed

Coxam,B., Sabine, A.,  Bower, N.I.,  Smith, K.A., Pichol-Thievend, C., Skoczylas, R., Astin, J.W., Frampton, E., Jaquet, M.,Crosier, Parton, R.G., Harvey, N.L., Petrova, T.V., Schulte-Merker, S.M., Francois, M., Hogan, B.M. Pkd1 regulates lymphatic vascular morphogenesis during development, Cell Reports, 7, 623-33, 2014. Pubmed

Ivanov, K.I., Agalarov, Y., Valmu, L., Samuilova, O., Liebl, J., Houhou, N., Maby-El Hajjami, H., Norrmén, C., Jaquet, M., Miura, N., Zangger, N., Ylä-Herttuala, S., Delorenzi, M.,& Petrova, T.V. Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells. Mol Cell Biol. 33, 3749-61, 2013. Pubmed

Jurisic*,G., Maby-El Hajjami*,H., Karaman,S., Ochsenbein. A., Siddiqui, S., Alitalo, A., Ochoa, C., Petrova, T.V., & Detmar, M., An unexpected role of semaphorin3A/neuropilin-1 signaling in lymphatic vessel maturation, Circ Res, 111, 426-36, 2012. *-equal contribution Pubmed

Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., Calmes, J.-M.,  Adams, R.H.,  Mäkinen, T., Kiefer, B., Kwak, B.R.& Petrova, T.V Mechanotransduction, PROX1 and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic valve formation. Dev. Cell, 22, 420-445, 2012. Pubmed
- selected for preview article “The Ebb and Flow of Lymphatic Valve Formation”, Dev Cell, 22, 242-243
- featured in Cell Press Webinar  “Morphogenesis: Insights from Darren Gilmour, Tatiana Petrova, and Yoshiki Sasai”

Skog M., Bono, P., Lundin, M., Lundin, J., Louhimo, J., Linder, N., Petrova T.V., Andersson, L.C., Joensuu, H., Alitalo, K., Haglund, C.H. Expression and prognostic value of transcription factor PROX1 in colorectal cancer. Br J Cancer. 105, 1346-51, 2011 Pubmed

Reviews

Sabine A, Saygili Demir C, Petrova TV. Endothelial Cell Responses to Biomechanical Forces in Lymphatic Vessels. Antioxid Redox Signal, 25(7):451–65, 2016 Pubmed

Bernier-Latmani, J., Sabine, A., & Petrova, T.V. Meet me in the middle: dual origin of dermal lymphatic vasculature. Circ Res, 2015 Pubmed

Coso, S., Bovay, E., & Petrova T.V Pushing the right buttons: signaling in lymphangiogenesis. Blood, 123, 2614-24, 2014 Pubmed

Meens, M.J., Sabine, A., Petrova T.V., Kwak B.R. Connexins in lymphatic vessel physiology and disease. FEBS Lett. 588,1271-7, 2014 Pubmed

Schulte-Merker, S., Sabine, A., & Petrova T.V. Lymphatic vascular morphogenesis in development, physiology and disease. J Cell Biol., 193, 607-18, 2011 Pubmed

Norrmén C, Tammela T, Petrova T.V., Alitalo K. Biological basis of therapeutic lymphangiogenesis. Circulation. 123, 1335-51, 2011 Pubmed

Norrmén, C., Vandevelde, W., Ny, A., Saharinen, P., Gentile, M., Haraldsen, G., Puolakkainen, P., Lukanidin, E., Dewerchin, M., Alitalo, K.* & Petrova, T.V.* Liprin ß1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood, 115, 906-9, 2010 Pubmed   

Kim, H., Nguyen, V.P., Petrova, T.V., Cruz, M., Alitalo, K.,& Dumont, D.J. Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol. 10, 72, 2010 Pubmed          

Norrmén, C., Ivanov, K.I., Cheng, J., Zangger, N., Delorenzi, M., Jaquet, M., Miura, N., Puolakkainen, P., Horsley, V., Hu, J., Augustin, H.G., Ylä-Herttuala, S., Alitalo, K. & Petrova, T.V. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J. Cell. Biol., 185, 439-57, 2009 (journal cover and In Focus editorial article) Pubmed   

Mouta-Bellum, C., Kirov, A., Miceli-Libby, L., Mancini, M.L., Petrova, T.V., Liaw, L., Prudovsky, I., Thorpe, P.E., Miura, N., Cantley, L.C., Alitalo, K., Fruman, D.A.&Vary, C.P.  Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dynam., 238, 2670-9, 2009 Pubmed

Thiel, A., Ganesan, A., Mrena, J., Junnila, J., Nykänen, A.,Hemmes, A., Tai,H.H., Monni, O., Kokkola, A., Haglund, C., Petrova, T.V., &Ristimäki, A. 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer Clin. Cancer Res., 15, 4572-80, 2009 Pubmed

Kirjavainen, A., Sulg, M., Heyd, F., Alitalo, K., Ylä-Herttuala, S., Möröy, T., Petrova, T.V., Pirvola, U. Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Dev Biol., 322, 33-45 , 2008 Pubmed    

Petrova, T.V., Bono, P., Holnthoner,W.,  Chesnes,  J.,Pytowski, B., Sihto, H., Laakkonen, P., Heikkilä, P.,  Joensuu, H.,&Alitalo, K., VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors, Cancer Cell, 13, 554-56, 2008 Pubmed     

Petrova, T.V.,* Nykänen, A., Norrmén,C., Ivanov, K.I., Andersson, L.C., Haglund, C.,  Puolakkainen, P.,Wempe, F., von Melchner, H., Gradwohl, G., Vanharanta, S., Aaltonen, L.A., Saharinen, J., Gentile, M., Clarke, A., Taipale, J., Oliver, G., & Alitalo, K.* Homeobox transcription factor PROX1 induces progression of colon cancer by promoting the transition from benign to highly dysplastic phenotype, Cancer Cell,  13, 407-19, 2008, *-corresponding authors    

Tammela T., Saaristo A., Holopainen T., Lyytikkä J., Kotronen A., Pitkonen M., Abo-Ramadan U., Ylä-Herttuala S., Petrova T.V. & Alitalo K. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nature Medicine, 13, 1458-66, 2007

Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C. Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 25, 1160-74, 2006.      

Kreuger J, Nilsson I, Kerjaschki D, Petrova T, Alitalo K, Claesson-Welsh L. Early Lymph Vessel Development From Embryonic Stem Cells.  Arterioscler Thromb Vasc Biol., 26,1073-78, 2006

Baluk, P., Tammela, T., Ator,E., Lyubinskaya, N., Achen, M.G., Hicklin, D.J., Jeltsch, M., Petrova, T.V., Pytkowski, B., Stacker, S.A., Ylä-Herttuala, S.,Jackson, D.G., Alitalo, K., and McDonald, D.M.  Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation, J. Clin. Invest., 115, 247-257, 2005.

Reviews

Maby-El Hajjami H, & Petrova T.V. Developmental and pathological lymphangiogenesis: from models to human disease. Histochem Cell Biol. 130, 1063-78, 2008.

Makinen T, Norrmen C, & Petrova T.V. Molecular mechanisms of lymphatic vascular development. Cell Mol Life Sci., 64, 1915-29, 2007

Alitalo, K., Tammela,T., and Petrova T.V. Lymphangiogenesis in development and human disease. Nature, 38, 946-953, 2005 

Tammela,T., Petrova T.V., and Alitalo, K. Molecular lymphangiogenesis: new players. Trends Cell Biol. 15, 434-441, 2005.

Petrova, T.V., Karpanen, T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Yla-Herttuala S, Miura N, Alitalo K. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nature Medicine, 10, 974-981, 2004 (journal cover).          

Kerjaschki, D., Regele, H.M., Moosberger, I., Nagy-Bojarski, K., Watschinger, B., Soleiman, A., Birner , P., Krieger, S., Hovorka, A., Silberhumer, G., Laakkonen, P., Petrova, T., Langer, B., Raab, I.  Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates.  J. Am. Soc Nephrol.,15, 603-12, 2004.   

Karkkainen, M. J., Haiko, P., Sainio, K., Partanen, J., Taipale, J., Petrova, T., Jeltsch, M., Jackson, D. G., Talikka, M., Rauvala, H., Betsholtz, C., and Alitalo, K. VEGF-C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat. Immunology 5, 74-80, 2004 (journal cover),

Veikkola,T., Lohela, M., Ikenberg, K., Mäkinen, T., Korff, T.,Saaristo,  Petrova T.,  A., Jeltsch,M., Augustin, H.G., and Alitalo, K. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.  FASEB J., 17, 2006-2013, 2004.   

Petrova T.V, Makinen T, Makela TP, Saarela J, Virtanen I, Ferrell RE, Finegold DN, Kerjaschki D, Yla-Herttuala S, and Alitalo K. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 21, 4593-4599, 2002. 

Iljin, K., Petrova, T.V., Veikkola, T., Kumar, V., Poutanen, M., and Alitalo, K. A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos.  FASEB J. 16, 1764-1774,2002.      

Veikkola T., Jussila L., Makinen T., Karpanen T., Jeltsch M., Petrova T.V., Kubo H., Thurston G., McDonald D.M., Achen M.G., Stacker, S.A., Alitalo K., Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice EMBO J. 20, 1223-31, 2001. 

Baladi S., Tsvetkov P.O., Petrova T.V., Takagi T., Sakamoto H., Lobachov V.M., Makarov A.A., and Cox JA. Folding units in calcium vector protein of amphioxus: Structural and functional properties of its  amino- and carboxy-terminal halves. Protein Sci. 10, 771-8, 2001. 

Koppal, T., Petrova, T.V., and Van Eldik, L.J. Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Brain Res., 867, 115-121, 2000.       

Petrova, T.V., Hu, J., and Van Eldik, L.J. Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures. Brain Res., 853, 74-80, 2000

Book chapters

Sabine, A., & Petrova, T.V. “Roles of connexins, calcineruin and Foxc2 in lymphatic vasculature” in "Advances in Anatomy, Embryology and Cell Biology", vol. 214, Springer, eds. S. Schulte-Merker &F. Kiefer, in press

Bernier-Latmani, J., Sabine, A.,& Petrova, T.V. How to build a drain to the vein: molecular mechanisms of lymphatic vascular development and function,  in  “Vascular Signaling in Health and Disease”, Springer, eds. M. Schmidt & S. Liebner, in press

Petrova T.V. and Cox J.A.  “Sarcoplasmic Ca2+-binding proteins and calerythrin” , Guidebook to the Calcium-binding proteins”, 1996, eds. M.R. Celio, co-eds. T.Pauls and B. Schwaller, Sambrook & Tooze Publication at Oxford University press, p. 65-67

Petrova T.V. and Cox J.A “Ca2+-vector protein” in “Guidebook to the Calcium-binding proteins”, 1996, eds. M.R. Celio, co-eds. T.Pauls and B. Schwaller, Sambrook & Tooze Publication at Oxford University press, p. 77-80  

 
Editorials

Fifteen years of molecular lymphangiogenesis - an interview with Kari Alitalo by Tatiana Petrova. Int J Dev Biol. 55,389-94, 2011.