Publications

Unisciences, publications: www.unil.ch/unisciences/nicoledeglon

ORCID (Open Researcher and Contributor ID): 0000-0003-4475-9476

Thomson Reuters Research ID: A-2265-2012

Gomez-Murcia, V., Launay, A., Carvalho, K., Burgard , A., Meriaux C., Caillierez, R., Eddarkaoui, S., Kilinc, D., Siedlecki, D., Besegher, M., Bégard, S., Thiroux, B., Jung, M., Nebie, O., Wisztorski, M., Déglon, N., Montmasson C., Bemelmans, A.-P., Hamdane, M., Lebouvier, T., Vieau, D., Fournier, I., Buee, L., Lévi, S., Lopes, L.V., Boutillier, A.-L., Faivre, E., Blum, D. (2023). Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice. Brain 147: 2691-2705.

Louessard M., Cailleret M., Jarrige M., Bigarreau J., Lenoir S., Dufour, N., Rey, M., Saudou F., Déglon N., Perrier, A.L. (2024). Mono and biallelic inactivation of Huntingtin gene in patient-specific iPS cells reveal HTT roles in striatal development and neuronal functions. J. Hunting. Dis. 13: 41-53.

Déglon N. (2024). Gene editing as a therapeutic strategy for spinocerebellar ataxia type-3. Revue Neurologique 180: 378-382.

Regio, S., Vachey, G., Goñi, E., Duarte, F., Rybarikova, M., Sipion, M., Rey, M., Huarte, M., and Déglon, N. (2023). Revisiting the outcome of adult wild-type Htt inactivation in the context of HTT-lowering strategies for Huntington’s disease. Brain Comm. 5(6):fcad344. doi: 10.1093/braincomms/fcad344

Duarte, F., Vachey, G., Caron, N.S., Sipion, M., Rey, M., Perrier, A.L., Hayden, M.R. and Déglon, N. (2023). Limitations of dual-sgRNA CRISPR strategies for the treatment of CNS genetic disorders. Hum. Gene Ther. 34: 958-974

Petrelli, F., Zehnder, T., Laugeray, A., Calì, C., Pucci, L., Molinero Perez, A., Bondiolotti, B.M., Mondoloni, S., De Oliveira Figueiredo, E.C.,  Dallerac, G., Déglon, N., Giros, B., Magara, F., Magrassi, L., Mothet, J.-P., Mameli, M., Simmler, L. and Bezzi, P. (2023). Disruption of astrocyte-dependent dopamine control in the developing medial prefrontal cortex leads to excessive grooming in mice. Biol. Psych. 93: 966-975

Duarte, F., Ramosaj M., Hasanovic, E., Regio, S., Sipion, M., Rey, M. and Déglon, N. (2023). Semi-automated workflows to quantify AAV transduction in multiple brain regions and predict gene editing outcome for neurological disorders. Mol. Ther. Methods Clin. Dev. 29: 254-270.

Perbet, R., Zufferey, V., Leroux, E., Espourteille, J., Parietti, E., Culebras, L., Perriot, S., Du Pasquier, R., Bégard, S., Deramecourt, V., Déglon, N., Toni, N., Buée, L., Colin, M. and Richetin, K. (2023). Accumulation of Tau in Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System. Cells 12: 985.

Denechaud M, Geurs S, Comptdaer T, Bégard S, Garcia-Núñez A, Pechereau LA, Bouillet T, Vermeiren Y, De Deyn PP, Perbet R, Deramecourt V, Maurage CA, Vanderhaegen M, Vanuytven S, Lefebvre B, Bogaert E, Déglon N, Voet T, Colin M, Buée L, Dermaut B, Galas MC. (2023). Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer’s disease. Prog. Neurobiol. 23: 102386

Rybarikova, M., Almacellas Barbanoj, A., Schorge, S., Déglon, N. (2022). CNS gene therapy: present developments and emerging trends accelerating industry-academia pathways. Hum. Gene Ther. 33: 913-922

Leroux, E., Perbet, R., Caillerez, R., Richetin, K., Lieger, S., Espourteille, J., Bouillet, T., Bégard, S., Danis, C., Loyens, A., Toni, N., Déglon, N., Deramecourt, V., Schraen-Maschke, S., Buée, L. and Colin, M. (2022). Extracellular vesicles: major actors of heterogeneity in tau spreading among human tauopathies. Mol. Ther. 30(2):782-797.

Thiebaut, A.M., Buendia, I., Ginet, V., Lemarchand, E., Boudjadja, M.B., Hommet, Y., Lebouvier, L., Lechevallier, C., Maillasson, M., Hedou, E., Déglon, N., Oury, F., Rubio, M., Montaner, J., Puyal, J., Vivien, D., Roussel, B.D. (2021). Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia. Autophagy, 18: 1297-1317.

Roumes, H., Jollé, C., Blanc, J., Benkhaled, I., Chatain, C., Massot, P., Raffard, G., Bouchaud, V., Biran, M., Pythoud, C., Déglon, N., Zimmer, E.R., Pellerin, L. and Bouzier-Sore, A.-C. (2021). Lactate transpoters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance. PNAS 118(47):e2112466118

Petrelli, F., Zehnder, T., Pucci, L., Cali’, C., Bondiolotti, B.M., Molinero Perez, A., Dallerac, G., Déglon, N., Giros, B., Magara, F., Magrassi, L., Mothet, J.-P., Simmler, L., and Bezzi, P. (2021). Astrocytic VMAT2 in the developing prefrontal cortex is required for normal grooming behavior in mice. bioRxiv, DOI: 10.1101/2021.01.27.428434

Zehnder, T., Petrelli, F., Romanos, J., De Oliveira Figueiredo, E.C., Lewis, T.L., Déglon N., Polleux, F., Santello, M. and Bezzi, P. (2021). Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation. Cell Rep. 35(2):108952.

Humbel, M., Ramosaj, M., Zimmer, V., Aeby, L., Moser, S., Sipion, M., Boizot, A., Rey, M. And Déglon N. (2021). Maximizing gene transfer and therapeutic efficacy in the CNS. Gene Ther. 28: 75-88

Cresto, N., Gaillard, M.C., Gardier, C., Gubinelli, F., Diguet, E., Bellet, D., Legroux, L., Mitja, J., Auregan, G., Guillermier, M., Josephine, C., Jan, C., Dufour, N., Joliot, A., Hantraye, P., Bonvento, G., Déglon, N., Bemelmans, A.P., Cambon, K., Liot, G., Brouillet, E. (2020). The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo. Neurobiol. Dis. 134: 104614

Portal, B., Delcourte, S., Rovera, R., Lejards, C., Lorenzo, N., Malnou, C., Haddjeri, N., Déglon, N., Guiard, B.P. (2020). Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs. Acta Physiol. 229: e13440

Petrelli, F., Dallérac, G., Pucci, L., Cali, C., Zehnder, T., Sultan, S., Lecca, S., Chicca, A., Ivanov, A., Asensio, C. Gundersen, V., Toni, N., Knott, G., Magara, F., Gertsch, J., Kirchhoff, F., Déglon, Giros, B., Edwards, R., Mothet J.-P., Bezzi, P. (2020). Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Mol. Psychiatry 25: 732-749

Uldry, F., Decembrini, S., Gamm, D.M., Déglon, N., Kostic, C., and Arsenijevic, Y. (2020). Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level. Sci. Reports 10: 8890

Droguerre, M., Duchêne, A., Picoli, C., Portal, B., Lajards, C., Guiard, B. P., Meunier, J,. Villard, V., Déglon, N., Hamon, M., Mouthon, F., Charvériat, M. (2020). Efficacy of THN201, a combination of donepezil and mefloquine, to reverse neurocognitive deficits in Alzheimer's disease. Front. Neurosci. 14: 563

Hirbec, H., Déglon, N., Foo, L.C., Goshen, I., Grudzendler, J., Hangen, E., Kreisel, T., Muffat, J., Regio, S., Rion, S., Escartin, C. (2020). Emerging technologies to study glial cells. Glia 68:1692–1728

Duarte, F. and Déglon, N. (2020). Genome Editing for CNS Disorders. Front. Neurosci. 14: 579062

Jimenez-Blasco, D., Busquets-Garcia, A., Hebert-Chatelain, E., Serrat, R., Vicente-Gutierrez, C., Ioannidou, C., Gómez-Sotres, P., Lopez-Fabuel, I,. Resch-Beusher, M., Resel, E., Arnouil, D., Saraswat, D., Varilh, M., Cannich, A., Julio-Kalajzic, F., Bonilla-Del Río, I., Almeida, A., Puente, N., Achicallende, S., Lopez-Rodriguez, M.L., Jollé, C., Déglon, N., Pellerin, L., Josephine, C., Bonvento, G., Panatier, A., Lutz, B., Piazza, P.V., Guzmán, M., Bellocchio, L., Bouzier-Sore, A.K., Grandes, P., Bolaños, J.P., Marsicano, G. (2020). Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. 563: 603-608.

Richetin, K., Pachoud, M., Maheswaran, M., Bégard, S., Pythoud, C., Rey, M., Caillierez, R., Leuba, G., Halliez, S., Bezzi, P., Buée, L., Colin, M., Toni, N., and Déglon, N. (2020). 1N3R tau accumulation in hilar astrocytes induces neuronal dysfunction and memory deficits in Alzheimer’s disease. Nat. Neurosci. 23: 1567-1579.

Merienne, N., Meunier, C, Schneider, A., Seguin, J. Nair, S.S., Rocher, A. B, Le Gras, S., Keime, C., Faull, R., Pellerin, L. Chatton, J.-Y, Néri, C., Merienne, K., Déglon, N. (2019). Cell-type-specific gene expression profiling in adult mouse brain reveals normal and disease-state signatures. Cell Reports 26, 2477–2493

Merienne, N., Vachey, G., de Longprez, L., Meunier, C., Zimmer, V., Perriard, G., Canales M., Mathias, A., Hergott, L, Beltraminelli, T., Maulet, A., Dequesne, T., Pythoud, C., Rey, M., Pellerin, L., Brouillet, E., Perrier, A., du Pasquier, R., Déglon, N. (2017). The self-inactivating KamiCas9 system for the editing of CNS disease genes. Cell Reports 20: 2980-2991.

Merienne, N., Delzor, A., Viret, A., Dufour, N., Rey, M., Hantraye, P. and Déglon, N. (2015) Gene transfer engineering for astrocyte-specific silencing in the CNS. Gene Ther. 22: 830-839

Drouet, V., Perrin, V., Hassig, R., Dufour N., Alves, S., Bonvento, G., Brouillet, E., Luthi-Carter, R., Hantraye, P. and Déglon N. (2009). Sustained effects of non-allele-specific huntingtin silencing. Ann. Neurol. 65: 276-285

Palfi, S., Brouillet, E., Jarraya, B., Bloch, J., Jan, C., Shin, M., Condé, F., Li, X.-J., Aebischer, P., Hantraye, P., and Déglon N. (2007). Expression of an N-terminal fragment of mutated huntingtin in the lateral putamen is sufficient to produce abnormal movements in non-human primates. Mol. Ther. 15: 1444-1451

de Almeida P.L., Ross C. A., Zala,D., Aebischer,P. and Déglon, N. (2002). Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels and protein length. J. Neurosci. 22: 3473-3483

Kordower, J. H., Emborg, M., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J., Chen, E.-Y., Palfi, S., Roitberg, B. Z., Brown, D., Holden, J., Pyzalski, R., Taylor, M. D., Carvey, P., Ling, Z.D., Trono, D., Hantraye, P., Déglon, N. and Aebischer, P. (2000). Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773

Déglon, N., Tseng, J.L., Bensadoun, J.-C., Zurn, A.D., Arsenijevic, Y., Pereira de Almeida, L., Zufferey, R., Trono and Aebischer, P. (2000). Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson’s disease. Hum. Gene Ther. 11, 179-190