Laboratories |
Thesis Directors |
Subject proposed |
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Anesthesiology - CEMIC |
Berna Renella Chantal (**) |
The neuroscience of mind-body techniques for pain relief: Chronic pain appears to be associated with a dysregulation in the stress response. Diffrenet mind-body techniques derived from complementary medicine (such as meditation or hypnosis) as well as modern tools such as biofeedback or vagus nerve stimulation could help with the regulation of this response. These techniques have only little been investigated from this mechanistic perspective in patients with chronic pain. Our lab has developped a specific stress induction technique that allows to expand on this line of research, using psychophysical monitoring (HRV, GSR, EEG), questionnaires and biological markers. Furthermore, clinical populations in acute situations of physiological stress (surgery, ICU) will be investigated in parallel with similar perspectives and questions regarding stress resiliance.
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Biomedical sciences |
Amati Francesca (**) |
Inter-organelle communication, translational research in aging and muscle metabolism: Novel highlights in the role and function of perilipid droplet mitochondria and other tethers
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Biomedical sciences |
Diviani Dario (**) |
Study of the pathophysiological mechanims promoting protection against heart failure: Investigating the molecular basis of cardiac repair in injured and stressed hearts.
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Biomedical sciences |
Habib Shukry James (**) |
Bioengineering, Stem Cell Biology and Regenerative Medicine: Developing A Novel Stem Cell Bandage For Bone Repair
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Biomedical sciences |
Knobloch Marlen (**) |
The role of lipid droplets in the healthy and aging brain
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Biomedical sciences |
Langlet Fanny (**) |
Glia-neuron communication in the regulation of energy balance: Investigating tanycyte-dependant synaptic plasticity on hypothalamic neurons regulating food intake in mice
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Biomedical sciences |
Widmann Christian (*) |
Cell-penetrating peptide and homeoprotein uptake mechanisms: The current focus of our laboratory is to characterize the mechanism of CPP cell entry via direct translocation or via endocytosis and how they escape endosomes when they use this later entry route. We also investigate how physiological molecules that naturally bear cell-penetrating sequences, such as homeoproteins, enter cells
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Center for Integrative Genomics |
Benton Richard (*) |
Evolution of neural circuit structure and function
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Center for Integrative Genomics
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Croizier Sophie (*) |
Deciphering the genetic and anatomic complexity of hypothalamic circuits: Sexually dimorphic development of hypothalamic feeding-circuits
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Center for Integrative Genomics |
Fankhauser Christian (*) |
Light and temperature regulated plant development
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Center for Integrative Genomics |
Gambetta Maria Cristina (*) |
Molecular basis of gene regulation specificity: Regulatory elements that activate or silence gene transcription are promiscuous and can act over long genomic distances in animals. We study how chromosome folding in 3D correctly wires regulatory elements to their target promoters.
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Center for Integrative Genomics |
Gatfield David (**) |
RNA biology and circadian clocks: Different topics available in the larger context of post-transcriptional / translational regulation of gene expression and circadian timekeeping. Projects can go from in vitro to cellular models and animal work (mice), as well as bioinformatics - depending on interest and qualifications.
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Center for Integrative Genomics |
Michalik Liliane (*) |
The responses of the skin to environmental insults: understanding how misregulated gene expression programs cause diseases. |
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Center for Integrative Genomics |
Roignant Jean-Yves (**) |
Regulation of gene expression by RNA modifications: These dynamic chemical marks can strongly impact how cells respond to environmental stimuli and their alteration are often linked to human disease. This project will be performed in collaboration with international teams and involved the usage of state-of-the-art molecular and genetic approaches to reveal the hidden code of this new layer of gene regulation. |
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Center for Integrative Genomics |
Soyk Sebastian (**) |
Dissecting genetic networks during stem cell development in crops: The aim of this PhD project will be to identify and characterize genes and gene networks that are involved in stem cell control and were selected during crop domestication and breeding.
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Center for Integrative Genomics |
Van Leeuwen Jolanda (*) |
Systematic analysis of genetic interactions: The deleteriousness of a mutation can depend upon the genetic background. For example, two patients carrying the same disease causal mutation may experience differences in disease severity. By mapping the effects of single and double mutants on a large scale, the student will try to understand when and how such genetic interactions occur.
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Clinical Neurosciences |
De Lucia Marzia (**) |
Sensory processing across conscious and unconscious state in humans (coma, sleep): Encoding of global auditory regularities in unconscious states
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Clinical Neurosciences |
Herbette Sonia (**)
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Cognitive neurosciences, stroke and brain reorganization: Modulation of brain activation and structure by cognitive training in stroke patients and healthy subjects
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Clinical Neurosciences |
Serino Andrea (*) |
Assessing body perception in healthy subjects and patients with sensorimotor deficits |
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Computational Biology |
Ciriello Giovanni (*) |
Computational Oncology: Cancer Evolution / Cancer cell plasticity / Genome 3D architecture
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Computational Biology |
Dal Co Alma (**) |
Ecology of Microbial Systems. WE ask: Can we predict the dynamics of microbial systems if we know how the individual cells interact? We address this question with single-cell experiments and mathematical modeling.
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Computational Biology |
Dessimoz Christophe (**) |
Reconstructing ancestral eukaryotic genomes by integrating large-scale genomic data: At the interface between biology and computer science, our laboratory seeks to better understand evolutionary and functional relationships between genes, genomes, and species. We have a number of ongoing projects in the lab—the research project will be discussed depending on the skills and interests of the candidates. More information on projects are available here: https://lab.dessimoz.org/research.
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Computational Biology |
Fasshauer Dirk (**) |
Molecular mechanisms of neuronal secretion
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