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Liens UNIL

Faculty of Biology and Medicine

Department of Fundamental Microbiology

Publications

Publications | Masters and Phd thesis

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Publications

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2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | ...

2021

PiggyBac transposase and transposon derivatives for gene transfer targeting the ribosomal DNA loci of CHO cells.

Bire S., Dusserre Y., Bigot Y., Mermod N., 2021/11/20. Journal of biotechnology, 341 pp. 103-112. Peer-reviewed.

[DOI][WoS][Pmid][serval:BIB_2E20E13CC582]

Rheological properties of skeletal muscles in a Duchenne muscular dystrophy murine model before and after autologous cell therapy.

Zemła J., Iyer P.S., Pyka-Fościak G., Mermod N., Lekka M., 2021/11/09. Journal of biomechanics, 128 p. 110770. Peer-reviewed.

[DOI][WoS][Pmid][serval:BIB_81DE96D7241D]

2020

preview resource BIB_BE8E8002A0B6.P001

Genome-wide analysis of single nucleotide variants allows for robust and accurate assessment of clonal derivation in cell lines used to produce biologics.

Kuhn A., Le Fourn V., Fisch I., Mermod N., 2020/12. Biotechnology and bioengineering, 117 (12) pp. 3628-3638. Peer-reviewed.

[URN][DOI][WoS][Pmid][serval:BIB_BE8E8002A0B6]

preview resource BIB_A31339F7E913.P001

Transient vitamin B5 starving improves mammalian cell homeostasis and protein production.

Pourcel L., Buron F., Garcia F., Delaloix M.S., Le Fourn V., Girod P.A., Mermod N., 2020/07. Metabolic engineering, 60 pp. 77-86. Peer-reviewed.

[URN][DOI][WoS][Pmid][serval:BIB_A31339F7E913]

preview resource BIB_D3B3130E78A9.P001

Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells.

Berger A., Le Fourn V., Masternak J., Regamey A., Bodenmann I., Girod P.A., Mermod N., 2020/04. Biotechnology and bioengineering, 117 (4) pp. 1101-1116. Peer-reviewed.

[URN][DOI][WoS][Pmid][serval:BIB_D3B3130E78A9]

preview resource BIB_02A3B3842F19.P001

Influence of cytoskeleton organization on recombinant protein expression by CHO cells.

Pourcel L., Buron F., Arib G., Le Fourn V., Regamey A., Bodenmann I., Girod P.A., Mermod N., 2020/04. Biotechnology and bioengineering, 117 (4) pp. 1117-1126. Peer-reviewed.

[URN][DOI][WoS][Pmid][serval:BIB_02A3B3842F19]

preview resource BIB_3F6D075DCCE1.P001

Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release.

Duroy P.O., Bosshard S., Schmid-Siegert E., Neuenschwander S., Arib G., Lemercier P., Masternak J., Roesch L., Buron F., Girod P.A. et al., 2020/02. Biotechnology and bioengineering, 117 (2) pp. 466-485. Peer-reviewed.

[URN][DOI][WoS][Pmid][serval:BIB_3F6D075DCCE1]

2019

Characterization of mesoangioblast cell fate and improved promyogenic potential of a satellite cell-like subpopulation upon transplantation in dystrophic murine muscles.

Mavoungou L.O., Neuenschwander S., Pham U., Iyer P.S., Mermod N., 2019/12. Stem cell research, 41 p. 101619. Peer-reviewed.

[DOI][WoS][Pmid][serval:BIB_2BB88877D39D]

A role for alternative end-joining factors in homologous recombination and genome editing in Chinese hamster ovary cells.

Bosshard S., Duroy P.O., Mermod N., 2019/10. DNA repair, 82 p. 102691. Peer-reviewed.

[DOI][WoS][Pmid][serval:BIB_A23C722A208B]

2018

Autologous Cell Therapy Approach for Duchenne Muscular Dystrophy using PiggyBac Transposons and Mesoangioblasts.

Iyer P.S., Mavoungou L.O., Ronzoni F., Zemla J., Schmid-Siegert E., Antonini S., Neff L.A., Dorchies O.M., Jaconi M., Lekka M. et al., 2018/04/04. Molecular therapy, 26 (4) pp. 1093-1108. Peer-reviewed.

[DOI][WoS][Pmid][serval:BIB_0BE77D405BD4]

2017

Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest

Droz X., Harraghy N., Lançon E., Le Fourn V., Calabrese D., Colombet T., Liechti P., Rida A., Girod P.A., Mermod N., 2017. Biotechnology and Bioengineering, 114 (8) pp. 1791-1802. Peer-reviewed.

[DOI][WoS][Pmid][serval:BIB_951315D027DD]

preview resource BIB_322831BD76E3.P001

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering.

Kostyrko K., Neuenschwander S., Junier T., Regamey A., Iseli C., Schmid-Siegert E., Bosshard S., Majocchi S., Le Fourn V., Girod P.A. et al., 2017. Biotechnology and Bioengineering, 114 (2) pp. 384-396. Peer-reviewed.

[URN][DOI][WoS][Pmid][serval:BIB_322831BD76E3]

2016

preview resource BIB_9C7D202B44D3.P001

Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.

Kostyrko K., Mermod N., 2016. Nucleic Acids Research, 44 (6) pp. e56. Peer-reviewed.

[URN][DOI][Pmid][serval:BIB_9C7D202B44D3]

preview resource BIB_000A07822074.P001

Development of a candidate reference material for adventitious virus detection in vaccine and biologicals manufacturing by deep sequencing.

Mee E.T., Preston M.D., Minor P.D., Schepelmann S., CS533 Study Participants, 2016. Vaccine, 34 (17) pp. 2035-2043.

[URN][DOI][WoS][Pmid][serval:BIB_000A07822074]

2015

Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.

Edelmann S., Fahrner R., Malinka T., Song B.H., Stroka D., Mermod N., 2015. Liver International, 35 (4) pp. 1185-1194.

[DOI][WoS][Pmid][serval:BIB_3109692321ED]

Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.

Harraghy N., Calabrese D., Fisch I., Girod P.A., LeFourn V., Regamey A., Mermod N., 2015. Biotechnology Journal, 10 (7) pp. 967-978.

[DOI][WoS][Pmid][serval:BIB_9CF43F1E2DD1]

A role for homologous recombination proteins in cell cycle regulation.

Kostyrko K., Bosshard S., Urban Z., Mermod N., 2015. Cell Cycle, 14 (17) pp. 2853-2861.

[DOI][WoS][Pmid][serval:BIB_677D328C43ED]

2014

preview resource BIB_DE99756211BD.P001

Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.

Deák F., Mátés L., Korpos E., Zvara A., Szénási T., Kiricsi M., Mendler L., Keller-Pintér A., Ozsvári B., Juhász H. et al., 2014. Journal of Cell Science, 127 (Pt 15) pp. 3240-3256.

[URN][DOI][WoS][Pmid][serval:BIB_DE99756211BD]

CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion.

Le Fourn V., Girod P.A., Buceta M., Regamey A., Mermod N., 2014. Metabolic Engineering, 21 pp. 91-102.

[DOI][WoS][Pmid][serval:BIB_C2E58E538DD5]

A PiggyBac-mediated approach for muscle gene transfer or cell therapy.

Ley D., Van Zwieten R., Puttini S., Iyer P., Cochard A., Mermod N., 2014. Stem Cell Research, 13 (3 Pt A) pp. 390-403.

[DOI][WoS][Pmid][serval:BIB_F2194B4273DB]

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Phd thesis

Publications (14)

preview resource BIB_20FC452BD829.P002

Study of DNA repair and recombination mechanisms in Chinese hamster ovary cells

Bosshard Sandra, 2019/05., Université de Lausanne, Faculté de biologie et médecine, Mermod Nicolas (dir.).

[URN][serval:BIB_20FC452BD829]

Assessment of a cell therapy approach for Duchenne muscular dystrophy using mesoangioblasts and non-viral vectors

IYER Pavithra, 2017., Université de Lausanne, Faculté de biologie et médecine, Mermod Nicolas (dir.).

[serval:BIB_691E33C8F51A]

preview resource BIB_533BFE2E0864.P001

The role of MAR elements in DNA recombination

Kostyrko K., 2015/08. 210, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[URN][serval:BIB_533BFE2E0864]

The role of NFI-C liver regeneration and its potential function as a general regulator of regenerative processes

Edelmann S., 2014. 153, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_BD8DF3F7B6DA]

Combining MAR elements and transposable vectors for more reliable transgene integration and expression

Ley D., 2014. 135, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_55E8B823B824]

Effects of epigenetic regulatory elements on telomeric gene expression

Majocchi S., 2012. 116, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_62FBBF385547]

Assessment of nuclear matrix attachment regions and atomic force microscopy for potential use in muscle cell therapy

van Zwieten R. W., 2012. 150, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_F8DD39BEB6CC]

Identification of Genetic Insulator Elements to Increase the Safety of Viral Gene Therapy Vectors

GAUSSIN Armelle, 2010., EPFL, Mermod Nicolas (dir.).

[serval:BIB_61F04C476F78]

Design and analysis of ChIP-Seq experiments for nuclear factor I DNA-binding proteins

Pjanic M., 2010. 233, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_10AB99C2A065]

Protein-Binding Microarray Technology and ChIP-Sequencing for the Identification of Novel Targets of the Human Tumor Suppressor AP2α

Kerschgens Jan, Mermod Nicolas, 2009., EPFL, Hubbell Jeffrey A. (dir.).

[serval:BIB_596DB8A14903]

Contribution of NFI-C to TGF-β1 signalling and tissue regeneration

Plasari G., 2009. 158, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_20BBB8F9771D]

preview resource BIB_CEA71D5DBA04.P001

Analyse des modifications de la chromatine impliquées dans l'effet barrière de CTF1 aux télomères humains

Esnault Germain, 2008. 106, Université de Lausanne, Faculté de biologie et médecine, Mermod Nicolas (dir.).

[URN][serval:BIB_CEA71D5DBA04]

Analysis of a boundary protein delimiting chromatin domains in yeast

Ferrari S., 2005. 153, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_43378]

Characterization of a plant-derived peptide displaying water clarifying and antimicrobial activities

Suarez M., 2005. 122, Université de Lausanne, Faculté de biologie et médecine, Mermod N. (dir.).

[serval:BIB_43380]

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