Radiation and immunotherapy

HERRERA Lab

Our focus

Our group is particularly interested in elucidating the molecular mechanisms by which ionizing radiation modulates tumor immunogenicity, as well as harnessing this attribute of radiation to induce therapeutic synergy with immunotherapy in pre-clinical tumor models and cancer patients. In human and mouse models, we orthogonally investigate the tumor microenvironment before and after radiation therapy and immunotherapy to capture tumor-immune cell interactions and comprehensively examine them in order to discover new pathways associated with successful immunological attack or immune failure. We are also conducting pre-clinical and clinical research on FLASH radiation therapy. We're looking at new ways to boost the therapeutic ratio of FLASH irradiation while also investigating its tissue-protective effects.

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KEY PUBLICATIONS

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CONTACT

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Fernanda HERRERA
Full professor - Senior physician
Laboratory F. Herrera (Service of radiation oncology)

Department of oncology UNIL CHUV

Phone +41 21 314 46 65
Email

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Featured Publication -------

Issue Cover

Low Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy.

This is the first study to mechanistically characterize the immune remodeling mechanisms of low-dose irradiation in order to improve immune checkpoint blockade efficacy in mouse models and metastatic cancer patients. This article paved the way for clinical trials combining immunotherapy and low-dose irradiation. DOI 10.1158/2159-8290.CD-21-0003 (2022)

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer ResearchUniversité de LausanneCentre Hospitalier Universitaire Vaudois (CHUV)