My research interests revolve around leveraging synthetic biology to improve immune effector cell therapies for solid tumors.
I completed my Ph.D. training at St. Jude Children’s Research Hospital in Memphis, TN, USA where my research focused on improving CAR T cell therapy for solid tumors via transgenic expression of engineered cytokine receptors or CRISPR/Cas9 knockout of negative regulators. In 2023, I joined the Gentner lab as a postdoctoral fellow.
Passionate about 3D models and tumor microenvironment, I want to leverage my immuno-oncology training to accelerate cancer research and propose efficient new therapeutic strategies for patients. In our team, we set out to tackle the immunosuppressive tumor microenvironment of ovarian cancer by cellular therapy approaches based on genetically-engineered human hematopoietic stem cells, with a focus on gynecological cancers, such as ovarian cancer. My mission as a postdoc is to build an in vitro platform using spheroids and organoids in co-culture with modified hHSC to study their infiltration and interaction with tumor cells, and validate these findings in xenograft mouse models.
After obtaining a master in oncology at University Paris-Saclay, I completed my PhD in immuno-oncology at the CRCT research institute (Pr Laurent team, Toulouse, France) supervised by Dr Bezombes (Toulouse, France) and co-supervised by Dr Pérez-Galán (Barcelona, Spain). During my training, I developed skills in 3D modelling, immunology and oncology. I am now a postdoc in Pr Gentner lab, working on ovarian cancer modelling and cellular therapy strategies using human hematopoietic stem cells.