Hi-TIDe : Immune monitoring and discovery

| Research interest | Research group projects | Selected Publications
 

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Alexandre HARARI
Privat-docent | Group leader
Human integrated tumor immunology discovery engine (Hi-TIDe)

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

Head of clinical Immune-monitoring core
Scientific deputy director of Center of experimental therapeutics

Phone +41 79 5567708
Email Alexandre.harari@chuv.ch

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Research interest

Our objective is to better understand two distinct components of the dynamic between tumors and T cells: what are tumor rejection antigens and what are the T-cell features associated with better efficacy. These are key questions in the development of novel personalized therapies. 

Research group projects

  • To develop a high-throughput platform to interrogate patients' immunity against private antigens and to identify highly-functional T cells (and TCRs) for ACT.
     
  • To identify biological and clinical correlates of the functional heterogeneity of neo-epitope-specific CD8 T cells.
     
  • To develop new tools to improve personalized cancer immunotherapy.

Selected Publications

  • B. Mastelic-Gavillet, B. Navarro Rodrigo, L. Décombaz, H. Wang, R. Ahmed, L. Derre, T. Nguyen-Ngoc, L. Kandalaft, G. Coukos, C. Jandus, C. Menetrier-Caux,5, C. Caux, P.C. Ho, P. Romero, A. Harari. & S. Viganó. Adenosine mediates peripheral and tumour-infiltrating CD8+ lymphocytes immunosuppression and metabolic rewiring through A2A/PKA/mTORC1 pathway. JITC (2019).

  • F.G. Herrera, M. Valerio, D. Berthold, J-Y. Meuwli, V. Vallet, P. Baumgartner, A.C. Thierry, P. Jichlinski, L. Kandalaft, G. Coukos, A. Harari & J. Bourhis. A Phase I Dose Escalation Study of Safety, Tolerability and Immunological Effects of Extreme Hypofraction Radiation Therapy to the Dominant Nodule in Patients with Intermediate and High-risk Prostate Cancer. International Journal of Radiation Oncology Biology Physics (2018).

  • J. L. Tanyi, S. Bobisse, E. Ophir, S. Tuyaerts, A. Roberti, R. Genolet, P. Baumgartner, B. J. Stevenson, C. Iseli, D. Dangaj, B. Czerniecki, A. Semilietof, J. Racle, A. Michel, I. Xenarios, C. Chiang, D. S. Monos, D. A. Torigian, H. L. Nisenbaum, O. Michielin, C. H. June, B. L. Levine, D. J Powel Jr, D. Gfeller, R. Mick, U. Dafni, V. Zoete, A. Harari, G. Coukos, L. E. Kandalaft. Personalized Cancer Vaccine Effectively Mobilizes Antitumor Immunity in Ovarian Cancer. Science Transl Med (2018).

  • S. Bobisse, R. Genolet, A. Roberti, J. L. Tanyi, J. Racle, B. J. Stevenson, C. Iseli, A. Michel, MA Le Bitoux, P. Guillaume, J. Schmidt, V. Bianchi, D. Dangaj, C. Fenwick, L. Derré, I. Xenarios, O. Michielin, P. Romero, D. S. Monos, V. Zoete, D. Gfeller, L. E. Kandalaft, G. Coukos, A. Harari. Sensitive and Frequent Identification of High Avidity Neo-epitope Specific CD8+ T-cells in Immunotherapy-naïve Ovarian Cancer. Nature Communications. (2018).

  • S. Bobisse, P. G. Foukas, G. Coukos & A. Harari. Neoantigen-Based Cancer Immunotherapy. Annals of Translational Medicine. (2016).

 

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Group members

  • Naoill ABDELAOUI
    Technician
  • Petra BAUMGARTNER
    Research Associate
  • Fabrizio BENEDETTI
    Bioinformatician
  • Sara BOBISSE
    Research Associate
  • Julien CESBRON
    Technician
  • Johanna CHIFFELLE
    PhD student
  • Raphael GENOLET
    Research Associate
  • Philippe GUILLAUME
    Research Associate
  • Andrea KOMLJENOVIC
    Postdoctoral Researcher
  • Sébastien LOFEK
    Technician
  • Alexandra MICHEL
    Technician
  • Baptiste MURGUES
    Technician
  • Blanca RODRIGO NAVARRO
    MD fellow and PhD student
  • Lise QUEIROZ
    Technician
  • Damien SAUGY
    Senior technician
  • Christophe SAUVAGE
    technician
  • Julien SCHMIDT
    Research Associate
  • Mathieu GUILLAUME
    Intern

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
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