Hi-TIDe : Immune monitoring and discovery

Our objective is to better understand two distinct components of the dynamic between tumors and T cells: what are tumor rejection antigens and what are the T-cell features associated with better efficacy. These are key questions in the development of novel personalized therapies. 

• To develop a high-throughput platform to interrogate patients' immunity against private antigens and to identify highly-functional T cells (and TCRs) for ACT.
   
• To identify biological and clinical correlates of the functional heterogeneity of neo-epitope-specific CD8 T cells.
   
• To develop new tools to improve personalized cancer immunotherapy.

• B. Mastelic-Gavillet, B. Navarro Rodrigo, L. Décombaz, H. Wang, R. Ahmed, L. Derre, T. Nguyen-Ngoc, L. Kandalaft, G. Coukos, C. Jandus, C. Menetrier-Caux,5, C. Caux, P.C. Ho, P. Romero, A. Harari. & S. Viganó. Adenosine mediates peripheral and tumour-infiltrating CD8+ lymphocytes immunosuppression and metabolic rewiring through A2A/PKA/mTORC1 pathway. JITC (2019).

• F.G. Herrera, M. Valerio, D. Berthold, J-Y. Meuwli, V. Vallet, P. Baumgartner, A.C. Thierry, P. Jichlinski, L. Kandalaft, G. Coukos, A. Harari & J. Bourhis. A Phase I Dose Escalation Study of Safety, Tolerability and Immunological Effects of Extreme Hypofraction Radiation Therapy to the Dominant Nodule in Patients with Intermediate and High-risk Prostate Cancer. International Journal of Radiation Oncology Biology Physics (2018).

• J. L. Tanyi, S. Bobisse, E. Ophir, S. Tuyaerts, A. Roberti, R. Genolet, P. Baumgartner, B. J. Stevenson, C. Iseli, D. Dangaj, B. Czerniecki, A. Semilietof, J. Racle, A. Michel, I. Xenarios, C. Chiang, D. S. Monos, D. A. Torigian, H. L. Nisenbaum, O. Michielin, C. H. June, B. L. Levine, D. J Powel Jr, D. Gfeller, R. Mick, U. Dafni, V. Zoete, A. Harari, G. Coukos, L. E. Kandalaft. Personalized Cancer Vaccine Effectively Mobilizes Antitumor Immunity in Ovarian Cancer. Science Transl Med (2018).

• S. Bobisse, R. Genolet, A. Roberti, J. L. Tanyi, J. Racle, B. J. Stevenson, C. Iseli, A. Michel, MA Le Bitoux, P. Guillaume, J. Schmidt, V. Bianchi, D. Dangaj, C. Fenwick, L. Derré, I. Xenarios, O. Michielin, P. Romero, D. S. Monos, V. Zoete, D. Gfeller, L. E. Kandalaft, G. Coukos, A. Harari. Sensitive and Frequent Identification of High Avidity Neo-epitope Specific CD8+ T-cells in Immunotherapy-naïve Ovarian Cancer. Nature Communications. (2018).

• S. Bobisse, P. G. Foukas, G. Coukos & A. Harari. Neoantigen-Based Cancer Immunotherapy. Annals of Translational Medicine. (2016).