Harari Lab members

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Naoill ABDELAOUI
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Technician
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Marion ARNAUD
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Postdoctoral researcher
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Research interest

I am currently managing the immune-monitoring analyses of the NeoTIL clinical trial within the Hi-TIDe.

Background

I obtained a PhD in Personalized Cancer Immunotherapy from the University of Lausanne under the direction of Dr Alexandre Harari. During my PhD, I have worked on the development of NeoTIL, a novel strategy to generate adoptive cell transfer products for next-generation cellular immunotherapies.

Sara BOBISSE
Harari Lab Bobisse.JPG Research associate
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Research interest

As a senior scientist in the Hi-TIDe, I’m currently responsible for the high-throughput discovery and characterization of cellular immune responses directed against unknown, shared and private tumor epitopes and participate in the development of new adoptive cell therapy strategies. 

Background

After obtaining my Master’s in Medical Biotechnology in Padua and Molecular Biology, in Bologna, I undertook a PhD in Oncology at the University of Padua, which is where my first interest in T cell engineering, and clinically oriented immunotherapy protocols developed. I worked as researcher in diagnostic oncology (hereditary disorders) and immuno-oncology for five years at the Veneto Oncology Institute before joining the Department of oncology UNIL CHUV in 2013. As Postdoctoral fellow, I developed new immunological assays, performed immunological monitoring for clinical studies and worked at the identification of personal tumor epitopes among patients.

Julien CESBRON
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Technician
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Talita GEHRET
Harari Lab Talita Gehret-crop1666x1860.jpg Technician
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Research interest

I am involved in developing a high-throughput platform to interrogate patients' immunity against private antigens and to identify highly functional T cells (and TCRs) for adoptive cell therapy (ACT). I also take part in the analysis of the immunological status and immune responses of patients enrolled in clinical studies.

 Background

I graduated from the HES-SO Valais where I obtained my Master’s in Life Sciences - Applied Biosciences. During my studies and especially during my master’s thesis, I constructed and analyzed the expression of CAR molecules intended for use in ACT. I am currently working as a biomedical analysis technician within the Hi-TIDe.

 

Johanna CHIFFELLE
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PhD student
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Research interest

Having a deep interest in understanding human health and disease, I started a PhD in 2019 under the direction of Dr Alexandre Harari. My project focusses on the dynamics and profiles of bulk and tumor-specific TILs in personalized cellular immunotherapy.

Background

I am an Engineer in Life Sciences of the EPFL, the Swiss Federal Institute of Technology in Lausanne, specialized in molecular medicine and systems biology.

Raphael GENOLET
Harari Lab Raphael Genolet.jpg Research associate
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Research interest

Since joining the Hi-TIDe in 2013, I develop new molecular tools to analyze and characterize TCR.

Background

After a PhD in Molecular Biology at University of Lausanne in 2005, I moved to the CMU in Geneva to study the impact of rapamcyn on translation of oncogenes. In 2008, I joined the the Department of oncology UNIL CHUV in the laboratory of Pr Immanuel Luescher where I started to study CD8 T-cells and their receptor (TCR).

Philippe GUILLAUME
Harari Lab Philippe Guillaume.jpg Research associate
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Research interest

Design, engineering and application of pMHC class I and II molecules for the detection and isolation of antigen-specific T cells.

Background

I have a PhD in Biochemistry and Molecular Biology. In 1999, I joined the group of Pr Immanuel Luescher at the Lausanne Branch of Ludwig Institute for Cancer Research as a Postdoctoral fellow and subsequently as Assistant investigator and was the co-founder and co-manager of TCMetrix Ltd. I joined the Hi-TIDe in 2016 as Research associate and Manager of the Peptide and Tetramer Core Facility (PTCF).

Audrey KENNEL
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Technician
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Sébastien LOFEK
Harari Lab Sebastien Lofek-.jpg Technician
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Research interest

The focus of my present research is to investigate the alterations of the immune fitness in cancer patients. With this aim, together with Selena Vigano, we have been establishing multiple immunological assays, as well as academic and industrial collaborations.

Background

I have a Master's in Biology and Genetics. I worked in several laboratories specialized in human immunology (auto-immune disease, primary immunodeficiency, immuno-oncology) where I specialized my skills in flow cytometry, cellular biology and cell culture. 

Alexandra MICHEL
Harari Lab Alexandra Michel-crop321x311.jpg Technician
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Research interest

As a technician within the Hi-TIDe, I closely interact with different scientists, analyse and discuss data aiming at the development of new assays with a special focus on TCR cloning.

Background

After obtaining my Master’s in Biochemistry at the University of Geneva in 1994, I worked for Glaxo and Serono Pharmaceutical Research Institute in the Chemokines and Functional Genomics fields where I acquired a variety of techniques in molecular and cellular biology. In 2007, after the acquisition of Serono by MERCK, I worked as Technology expert on antibody humanisation, optimisation and characterisation. Since joining the Department of oncology UNIL CHUV in 2013, I performed, validated and implemented cellular and molecular assays to interrogate T cells from clinical samples for research and in the context of clinical trials (immunological monitoring).

Matthieu MUNIER
Harari Lab Matthieu Munier.jpg Technician
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Research interest

With a particular interest for clinical research in the domain of oncology, I joined the Hi-TIDe team  as a technician in November 2021. I am currently in charge of the mRNA production for the TCR screening team and also take part in the screening. I also participate in in vivo experiments and optimization of the in vitro screening strategy.

Background

I obtained my professional licence in “Molecular biology, tissue and cell cultures” in internship at the Interdisciplinary Institute for NeuroScience (IINS) in Bordeaux. I specialized in plasmid production and dissection of mouse brains to understand the behavior and role of synaptic adhesion molecules. 

Baptiste MURGUES
Harari Lab Baptiste Murgues.jpg Technician
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Rémy PETREMAND
Harari Lab Rémy_Pétremand-crop1714x2040.jpg PhD student
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Research interest

I am interested in molecular biology, data sciences and the intersection between them to address relevant questions in cancer biology. I am currently doing my PhD, under the direction of Dr Alexandre Harari, focussed on analyzing clinical data to better understand the dynamics of T cell populations in tumors by developing new computational tools and data-driven models.

Background

In 2020, I graduated in Life Sciences and Technology, with a minor in biocomputing, from EPFL, the Swiss Federal Institute of Technology in Lausanne. Within this programme, I developed a deep understanding of genomics, oncology and computer sciences. I went on to gain experience in single-cell RNA-sequencing analysis and developing statistical models during my master’s thesis at the University of Lausanne’s Department of computation biology and during an internship at Metadvice.

Lise QUEIROZ
Lise Queiroz-crop120x103.jpg Technician
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Blanca RODRIGO NAVARRO
Harari Lab Blanca Navarro.jpg MD fellow and PhD student
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Research interest

Investigation and translational analyses of the neoantigen landscape in colon cancer.

Background

I obtained my MD from the Medical School at the University of Valencia in 2009. After completing my specialization in medical oncology in 2015, I obtained an ESMO translational research fellowship and joined the Hi-TIDe. I am pursuing my translational and clinical research activities as MD-PhD student and as attending oncologist within the Service of immuno-oncology of the Department of oncology UNIL CHUV.

Damien SAUGY
Harari Lab Damien Saugy-crop466x450.png Senior technician
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Research interest

I joined the Hi-TIDe in 2020 to follow up with performing research projects in tumor immunology and participate to the development of new immunological assays. I contribute to the identification of tumor- and antigen-specific TCRs and at the automation of different screening approaches.

Christophe SAUVAGE
Harari Lab Sauvage Christophe-crop224x200.jpg Technician
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Research interest

In 2020, I joined the Department of oncology UNIL CHUV where I experienced in bulk TCR sequencing and HLA typing within the Hi-TIDe. My main current interest concerns the execution and amelioration of innovative techniques (i.e. single cell RNA sequencing; TCR cloning and tests) in immuno-oncology with future clinical applications.

Background

In 2000, after obtaining my “Brevet de Technicien Supérieur” in Biochemistry from Amiens (France), and a degree in cell and tissue culture from animal and plant origin at Dijon (Frace), I started to work as a technician for different biotechnology companies. First in an upstream small-scale bioreactor unit, and later in a cell line development unit. This position involved the design and realization of cell & molecular biology experiments to generate high-producing cellular clone with high quality of protein of interest.

Julien SCHMIDT
Harari Lab Schmidt Julien-crop226x257.png Research associate
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Research interest

New reagents to detect and characterize antigen-specific T cells.

Background

I gained my PhD in Chemical Biology at the University of Montpellier (France). In 2009, I joined the Lausanne branch of the Ludwig Institute for Cancer Research, as a member of laboratory of Pr Immanuel Luescher with whom I founded TCMetrix Ltd, with Philippe Guillaume. I later joined the Hi-TIDe where I took on the management of the Peptide & Tetramer Core Facility (PTCF).

Selena VIGANO
Harari Lab Selena Vigano-crop1744x1840.jpg Research associate
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Research interest

The focus of my present research is to investigate the alterations of the immune fitness in cancer patients. With this aim, together with Sebastien Lofek, we have been establishing multiple immunological assays, as well as academic and industrial collaborations.

Background

After my Master’s in Medical Biotechnology at the San Raffaele University, Milan in 2013, I obtained my PhD at the University of Lausanne, under the direction of Pr Giuseppe Pantaleo. My doctoral work focused on HIV-1 immunology and primary immunodeficiency. I then became a postdoctoral fellow in Pr Xu Yu’s team at Ragon Institute of MGH, MIT and Harvard. I returned to the University of Lausanne working in the lab of Pr Pedro Romero, in close collaboration with the Immunomonitoring core, headed by Dr Alexandre Harari. My work focused on the development of immunomonitoring tools and the investigation of mechanisms lying behind efficacy of new immunotherapies developed in the context of multiple collaborative EU-supported consortiums. In 2019, I joined the Hi-TIDe as Research associate within the Center of experimental therapeutics (CTE).

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CONTACT

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Alexandre HARARI
Group leader
Human integrated tumor immunology discovery engine (Hi-TIDe)

Department of oncology UNIL CHUV
Ludwig Institute for Cancer Research Lausanne

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Phone +41 79 5567708
E-mail

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The Harari Lab is based at:

AGORA Cancer Research Centre
Rue du Bugnon 25A
CH-1005 Lausanne
Switzerland

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Ch. des Boveresses 155 - CH-1066 Epalinges
Switzerland
Tel. +41 21 692 59 92
Fax +41 21 692 59 95
Ludwig Cancer Research Université de Lausanne Centre Hospitalier Universitaire Vaudois (CHUV)