I am a postdoctoral researcher in evolutionary biology and genome evolution. I use computational tools to study how our genome evolves, gets expressed and determines, in part, who we are.
During my PhD, I explored the evolution of the genome through duplications. Using simulations and comparative genomics, I studied duplicated and copy-number variant regions in primate genomes searching for potential consequences of such duplications in terms of molecular genomics and gene expression.
In my first postdoc, I worked on the genetic network of the placenta. The placenta is an organ that appeared in the early stages of mammal evolution. It specialized and diversified to give rise to a notable functional diversity among placental mammals. I investigated the protein coding and non-coding genes expressed in human and mouse placenta to learn about the placenta transcriptome and its evolution.
At that moment, I am working in the genomics of the European amphioxus (Branchiostoma lanceolatum) in collaboration with labs from the European Amphioxus Genome Consortium. Amphioxus is a slowly-evolving invertebrate chordate. This makes it a very good outgroup to study vertebrate origins. Moreover, amphioxus has particular genomic features such as very high heterozygosity rates. In my current project I am interested in understanding the functional impact of this high heterozygosity in amphioxus biology.
EDUCATION
2014 - 2019 PhD in Biomedicine, Pompeu Fabra University (UPF), Spain.
2012 - 2014 MSc in Bioinformatics for Health Sciences, Pompeu Fabra University (UPF) and University of Barcelona (UB), Spain.
2008 - 2012 BSc in Human Biology, Pompeu Fabra University (UPF), Spain.
RESEARCH AND TEACHING EXPERIENCE
2021 - Now Robinson-Rechavi Group - Evolutionary Bioinformatics, Department of Ecology and Evolution, Université de Lausanne (UNIL), Switzerland.
Postdoc in Genomics
Supervisor: Marc Robinson-Rechavi
2019 - 2021 Laboratoire de Biométrie et Biologie Evolutive (LBBE), Equipe Bioinformatique, Phylogénie et Génomique Evolutive, Université Claude Bernard Lyon I, France.
Postdoc in Genomics
Supervisor: Anamaria Necsulea
2014 - 2019 Evolutionary Genomics Lab and Comparative Genomics Lab, Institute of Evolutionary Biology (IBE) (UPF – CSIC), Pompeu Fabra University (UPF), Spain.
PhD in Biomedicine
Supervisors: Arcadi Navarro and Tomàs Marquès-Bonet
2013 - 2014 Evolutionary Genomics Lab, Institute of Evolutionary Biology (IBE) (UPF – CSIC), Pompeu Fabra University (UPF), Spain.
MSc Research Trainee
Supervisor: Arcadi Navarro
PUBLICATIONS
Brasó-Vives M, Povolotskaya IS, Hartasánchez DA, Farré X, Fernandez-Callejo M, Raveendran M, Harris RA, Rosene DL, Lorente-Galdos B, Navarro A, Marques-Bonet T, Rogers J, Juan D. Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta). PLoS Genet. 2020 May 11;16(5):e1008742.
Hartasánchez DA, Brasó-Vives M, Heredia-Genestar JM, Pybus M, Navarro A. Effect of Collapsed Duplications on Diversity Estimates: What to Expect. Genome Biol Evol. 2018 Nov 1;10(11):2899-2905.
Eraso-Pichot A, Brasó-Vives M, Golbano A, Menacho C, Claro E, Galea E, Masgrau R. GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes. Glia. 2018 Aug;66(8):1724-1735.
Gallego A, Hartasánchez DA, Brasó-Vives M, Garcia-Ramallo E, Lopez-Valenzuela M, Baena N, Guitart M, Fernández-Bellon H, Kondova I, Bontrop R, Kawahara Y, Espinosa-Parrilla Y. RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin. Gene. 2017 Sep 10;628:109-116.
Hartasánchez DA, Brasó-Vives M, Fuentes-Díaz J, Vallès-Codina O, Navarro A. SeDuS: segmental duplication simulator. Bioinformatics. 2016 Jan 1;32(1):148-50.
Hartasánchez DA, Vallès-Codina O, Brasó-Vives M, Navarro A. Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario. G3 (Bethesda). 2014 Jun 6;4(8):1479-89.
Under construction
